FUNCTIONAL INSIGHTS INTO PROTEIN KINASE A (PKA) SIGNALING FROM C. ELEGANS


Enhancing property and activity prediction and interpretation using multiple molecular graph representations with MMGX

Abstract Graph Neural Networks (GNNs) excel in compound property and activity prediction, but the choice of molecular graph representations significantly influences model learning and interpretation.While atom-level molecular graphs resemble natural topology, they overlook key substructures or functional groups and their interpretation partially al

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Cyclin D1 mediates pain behaviour in a rat model of breast cancer-induced bone pain by a mechanism involving regulation of the proliferation of spinal microglia

AimsThe involvement of cyclin D1 in the proliferation of microglia, and the generation and maintenance of Coffee Tables bone cancer pain (BCP), have not yet been clarified.We investigated the expression of microglia and cyclin D1, and the influences of cyclin D1 on pain threshold.MethodsFemale Sprague Dawley (SD) rats were used to establish a rat m

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